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Turkuaz & The New Mastersounds Teaming Up For Funky Chicago Throwdown

first_imgThe second best thing to happen to Chicago this month — behind the Cubs winning the World Series, of course — just might be two of the funkiest bands out there right now hitting Park West on 11/25. When it comes to modern funky music, not many are doing it better than Turkuaz and The New Mastersounds. Each band has been road-tested and fan-approved, bringing their big dance party sounds to fans across the country. When these groups share the stage, the energy is seriously through the roof. Get tickets to Turkuaz & the New Mastersounds at Park West here.Turkuaz & New Mastersounds Team Up For A Funky Colorado Throwdown [Review]The pairing between these two bands started last summer, when the bands got together after High Sierra Music Festival for a meeting of the minds at Sharkbite Studios in Oakland, CA. The resulting session saw each band cover a track from the other’s catalog, with their collaborative help, of course. The two tracks they laid down – Turkuaz’s rendition of NMS’s “On The Border” and New Mastersounds’ rendition of  Turkuaz’s “The Rules” – were recently released as the Split 7″ EP.Each show of their tour turns the energy up the max, as Turkuaz’s funk army style is matched by the chilled out funky grooves of The New Mastersounds. Expect exciting collaborations and non-stop dancing when these two bands come to town!The New Mastersounds & Turkuaz Share The Stage With Kofi Burbridge In Funky Florida Throwdown [Videos/Audio]Get tickets to Turkuaz and the New Mastersounds at Park West Chicago on 11/25 here, or enter to win them below.last_img read more


Topical treatment on hand for liver spots

first_imgAn investigation into the molecular mechanisms responsible for the most common type of benign skin lesion may lead to the first nonsurgical treatment for the growths called seborrheic keratoses (SKs), which can be cosmetically unattractive and often worrisome to patients. A paper by researchers at Harvard-affiliated Massachusetts General Hospital (MGH), published online in the Journal of Investigative Dermatology, reports that blocking the action of a specific signaling enzyme leads to the death of cultured SK cells and the breakdown of SK lesions.“Our paper is the first to show that SKs are dependent on an enzyme called Akt for survival,” said Victor Neel, director of dermatologic surgery at MGH and lead author of the paper. “Inhibition of this enzyme in SK cells causes rapid cell death while having no effect on normal skin cells. We are confident that this paper heralds the development of an effective, topical treatment for SKs.”Sometimes called senile warts, barnacles, or liver spots, SKs vary in color from tan to black, can be flat or raised, and range in size from quite small to an inch or more across. They become more common with aging; most individuals over 40 are likely to have a few, and some have hundreds scattered across the torso and face. While SKs have some microscopic features in common with their malignant counterpart squamous cell carcinoma and most have mutations in genes known to be involved in cancer, SKs never become malignant.Previous research by members of the MGH team identified increased expression in SKs of growth factor receptors and other genes thought to be involved in skin cell differentiation and in skin cancer development. Neel explained, “We still don’t know why SKs resist malignant transformation, but we think studying SKs will help us identify factors that prevent benign lesions from becoming malignant.”The two genes that are most frequently mutated in SKs — called PI3K and FGFR3 –— code for proteins that affect the activation of the Akt kinase enzyme, which is known to block several cell-death related pathways. Although previous studies have reported higher levels of activated Akt in SKs than in normal skin, determining the significance of that finding was hampered by the inability to grow SK cells in the laboratory. Through trial and error and a bit of luck, the MGH team identified conditions that permit SK cells to be cultured, opening up an array of opportunities for studying their biology.Cultured SK cells were exposed to a panel of specific kinase inhibitors, confirming that the development and maintenance of SK cells requires the presence of activated Akt. One particular Akt inhibitor, called A44 (A-443654, produced by Abbvie Pharmaceuticals), was by far the most efficient at inducing the death of cultured SK cells. Small doses of A44 initiated a cell-death program called apoptosis. The researchers also found that applying A44 to intact SK lesions that had been excised from patients’ skin and maintained in culture caused the lesions to die through apoptosis.“Within 48 hours of exposure to A44, the SK lesions from patients completely disintegrated,” said co-author Anna Mandinova of MGH’s Cutaneous Research Biology Center. “This effect was very specific to SK lesions, as A44 was harmless both to normal skin cells and to malignant squamous cell carcinoma cells.”The MGH team is continuing to investigate the potential of A44 and several other compounds to identify the best candidate for clinical trials of a topical treatment for SKs. A patent application based on the study findings has been filed, and the team is continuing to pursue what SKs can reveal about the molecular differences between benign and malignant tumors.“Understanding why SKs never become malignant, even though they have mutations in classic oncogenes, was the primary question we wanted to address when we started studying this skin lesion. Finding a novel inhibitor of SKs was a serendipitous byproduct of that inquiry,” says Neel, who is an assistant professor of dermatology at Harvard Medical School. “We suspect that other, yet-to-be-determined mutations in SKs are incompatible with the mutations that lead to malignancy. For example, p53 is commonly mutated both in sun-damaged skin and in cancers like squamous cell carcinoma, but is never mutated in SKs.“We hope that pinpointing other mutations underlying SK development will help us understand how they resist becoming malignant, which could inform us of new ways of treating more dangerous tumors.”last_img read more


David Beckham wants Real Madrid Galactico to manage Lionel Messi at Inter Miami

first_img How Everton could look in January under Ancelotti with new signings SORRY The average first-team salaries at every Premier League club in 2019 The former England captain exercised his contractual clause to start his own MLS team in January of this year and is already plotting manoeuvres to make them the biggest side in America.By the time Inter Miami are running in two years time, Messi will have two years left on his Barca deal aged 32 and may consider the move.And, according to the Daily Mirror, Becks wants his Galactico teammate Zidane to run the team.The Frenchman’s last job saw him retain the Champions League trophy for an incredible third time in a row before surprisingly quitting just days later. Boxing Day fixtures: All nine Premier League games live on talkSPORT predicted Sky Sports presenter apologises for remarks made during Neville’s racism discussion Most Popular Football Stories 2 Beckham and Messi could be reunited for Inter Miami CF 2 latest Although he has been linked with moves to Qatar, communications with close friend Beckham may convince him otherwise.Inter Miami will be based in a 70% Hispanic neighbourhood so the signing of a South American star would certainly appease the natives.When asked about the possibility of singing the five-time Balon d’Or winner, Beckham said: “Who knows maybe we can see him here in a few years time. BEST OF revealed gameday cracker Liverpool news live: Klopp reveals when Minamino will play and issues injury update England’s most successful clubs of the past decade, according to trophies won Every time Ally McCoist lost it on air in 2019, including funny XI reactions Gerrard launches furious touchline outburst as horror tackle on Barisic sparks chaos Zidane and Beckham are still firm friends silverware David Beckham has held ‘preliminary talks’ with former Real Madrid teammate Zinedine Zidane about managing his MLS team, Inter Miami CF.And he also wants to sign Barcelona superstar Lionel Messi once the franchise is up and running by 2020, according to reports. scrap “We want to create the biggest club in the USA and so that means attracting some of the biggest players.”The singing of Zidane would be seen as the more pressing matter for Beckham, with Manchester United circling as pressure grows on Jose Mourinho.It is understood he would prefer a move in Europe, but the pulling power of ‘Brand Beckham’ may convince him otherwise.last_img read more


Council may place art at Five-Points corner

first_img AD Quality Auto 360p 720p 1080p Top articles1/5READ MOREBlues bury Kings early with four first-period goals “I think that his contribution to our country is very significant,” Golonski said. “Lockheed was the big business here, and building planes was a big part of Burbank for a long time, and he played a big part in Burbank history.” The city has about $540,000 set aside for public art, and Vander Borght said the Five-Points project could cost up to $400,000, although the council hasn’t decided what the art project will be. Alex Dobuzinskis, (818) 546-3304 [email protected] 160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set! BURBANK – The Five-Points intersection is known for heavy traffic, but the Burbank City Council wants it to be known for something else – public art. The council voted 4-0 this week to install artwork on the one-acre site where Victory Boulevard, Victory Place and Burbank Boulevard meet. “I don’t see this as a park that will attract a lot of people,” Mayor Jef Vander Borght said. “I mean, there’s no room to do a play area or anything like that. It’s to generate a monument or a focal point for that intersection.” When the council voted on the project, Councilman Dave Golonski suggested creating a statue of the late airplane designer Clarence “Kelly” Johnson. While working for Lockheed Aircraft in Burbank, Johnson had a hand in designing some of the United States’ most important military aircraft, including the P-38 Lightning, the U-2 spy plane and the SR-71 Blackbird. last_img read more


Tragic Lyra had planned her wedding in Donegal mourners hear

first_imgA packed cathedral heard today that Lyra McKee had revealed her plans to propose to her partner Sara just hours before she was murdered.Speaking at St Anne’s in Belfast’s Donegal Street, Stephen Lusty said she showed him pictures of the engagement ring.Tragic Lyra had planned her wedding in Donegal mourners hear was last modified: April 27th, 2019 by Shaun KeenanShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:Lyra McKeelast_img read more


Seeing Africa in a new light

first_img10 October 2006By this time next year, global perceptions of Africa could be changing radically as two major new international television stations project a different image of the continent and provide African viewers with a global context to better understand global forces and seek advantage for the continent in trade, investment and tourism.The two new stations – CNBC Africa and Al Jazeera International, which are both set to go live in the next six months or so – will intensify the media spotlight on Africa at a time when the northern hemisphere view of the world is being increasingly challenged by economic realities and reforms at the United Nations and multilateral institutions.New global realitiesA recent cover story in the influential Economist pointed out that the developing world now accounts for more than 50% of global economic output measured in purchasing-power parity.The rise of major industrialising developing powers – such as China, India, Brazil, Mexico, South Korea and Turkey – have prompted reforms at the UN, IMF and World Bank as the global centre of gravity shifts closer to the developing countries.Major corporations in the developing countries – such as India’s Tata Industries and South Africa’s SABMiller – now account for more than a third of all foreign direct investment in the developing world.South-south co-operation is no longer a political slogan – it has become an economic reality. Increasingly, global economic growth depends on the economic growth of developing countries.24-hour Africa business channelIn recognition of these new realities – and the emergence of Africa as a major trade and investment partner of China and the new developing powers – CNBC, the global business TV leader, is set to open a 24-hour Africa business channel by mid-2007 with an initial investment of R190-million (roughly US$25-million).CNBC Africa, an autonomous unit with its headquarters in Johannesburg and set to train a new genetation of African financial journalists, will beam six hours of dedicated Africa programming each week day and will have correspondents in Cape Town, Nigeria, Kenya, Tanzania, Botswana and London. It will also incorporate its Asian, Middle Eastern and European services for its African viewers.Zafar Siddiqi, chairman of CNBC Africa, said that the new service would address dysfunctional broadcasting policies between African countries, poor communications and inadequate marketing on the continent and an over-sensationalisation of news.“We will set a new standard in broadcasting on the continent that will spur others … we will work closely with all broadcasters around Africa,” Siddiqi told the the first International Media Forum in Johannesburg last month.The Forum, which was partnered by the International Marketing Council of South Africa, sought to promote a dialogue between international media and South Africans about mutual perceptions of the country and the African continent.Al Jazeera: five new Africa bureauxAl Jazeera International, a new English-language station spawned by the successful Qatar-based Arabic station serving the Middle East, is due to go live before the end of the year with a 24-hour global news service with five bureaux in Africa.Al Jazeera has hired some of the top names in British journalism, including the legendary interviewer David Frost and former BBC heavyweight Nigel Parsons, who heads the station. It seeks to portray global news from a centre of gravity which lies outside of the industrialised world, and will portray global news from a developing world perspective, thus reflecting the new global realities.“We will set out to normalise news coverage in Africa,” said Andrew Simmonds, Al Jazeera International’s Africa bureau chief, who attended the Forum.The renewed interest in Africa is being driven by a confluence of forces: increased global interest in Africa’s rich resources – particularly oil and steel – the rapid rise of the continent as a destination for Chinese and Indian investment and trade, major growth in South African investment in Africa, and a deeper understanding of the link between terrorism, poverty and failed states.No built-in bias against AfricaDelegates to the International Media Forum heard a succession of influential speakers representing the world’s leading news organisations – CNBC, CNN, Al Jazeera, the Wall Street Journal, BBC, DowJones Newswires, Reuters and Africa Confidential – sketch the news global realities and the rising importance of Africa in a globalised world.The messages that come through repeatedly were that news organisations are driven by what their readers and subscribers want – rather than focussing on either negative or positive news – that there is no built-in bias against Africa, and that African countries and companies need to develop better communication strategies to compete in the global market place if ideas and enterprises.South African Minister in the Presidency Essop Pahad, who spoke at the conference, welcomed the tone of speeches from the international editors and suggested that South Africans should revisit the view that the global media was a monolithic bloc that sought to marginalise the continent and entrench negative stereotypes.“We cannot simply dismiss negative reportage as the product of the racist or the colonial mindset, nor must we paint all reporters with the same brush,” he said. “We also need to be more open to investigative journalism.”Randy Walerius, London-based Africa and Middle East editor at Dow Jones Newswires, said that the slogan and driving force of his news organisation was: “news to profit by”.“We don’t look at news as positive or negative,” he said. “It’s whether the news offers news [for readers and subscribers] to profit by.”Importance of open communicationThemba Maseko, the new director-general of South Africa’s Government Communication and Information System (GCIS), presented the government’s new communications strategy, which seeks to correct preceptions by clear and repeated communication of government policy and its achievements, and promised better access for journalists.Addressing a dinner of the international media and invited guests, Pahad suggested that the Forum should become a regular event on the annual calendar.The Forum kicked off an overdue debate between the international media and South African stakeholders in business and communications about differing domestic and international perceptions of South Africa and the importance of open and clear communication to promote good governance and economic transparency.South Africa’s challenge is to ensure that just as opportunities open up for Africa and South Africa with changing international perceptions, we do not become prisoners to our own stereotypes that global opinion is biased against us and always looking to reinforce the negative.It is time to open ourselves to international scrutiny and put our case more convincingly and more professionally.John Battersby is the UK country manager of the International Marketing Council of South Africa, based in London. He recently accompanied a group of leading international journalists, editors and managers on a visit to South Africa to attend the first International Media Forum. Want to use this article in your publication or on your website?See: Using SAinfo materiallast_img read more


Claudio Pizarro nets late to become Bundesliga’s oldest goal-scorer

first_imgView comments Oil plant explodes in Pampanga town It looked like Davie Selke’s first-half goal against his former side was enough for Hertha to win, but Pizarro came on as a substitute with half an hour remaining and had the final say.The veteran Peru striker also became the first to score in 21 different calendar years in the Bundesliga with his 195th league goal.FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSUrgent reply from Philippine ‍football chiefSPORTSPalace wants Cayetano’s PHISGOC Foundation probed over corruption chargesThe goal denied Hertha sixth place and kept 10th-placed Bremen one point behind the home side.STUTTGART DENIED Oil plant explodes in Pampanga town Private companies step in to help SEA Games hosting Grace Poe files bill to protect govt teachers from malicious accusations SEA Games hosting troubles anger Duterte Stuttgart’s hopes of a reprieve after another week of turbulence went unanswered as Leipzig won their game 3-1 to consolidate fourth place.Danish forward Yussuf Poulsen scored twice to help Leipzig move one point below Borussia Moenchengladbach and stay six clear of Wolfsburg, which defeated Mainz 2-0 at home.Stuttgart sought its first win in seven games to ease the pressure on coach Markus Weinzierl. Weinzierl kept his job after last weekend’s 3-0 loss at Fortuna Duesseldorf, but sporting director Michael Reschke was told to go on Tuesday.Former Aston Villa and Germany midfielder Thomas Hitzlsperger, who helped Stuttgart win the Bundesliga in 2007, was appointed in Reschke’s place.Stuttgart had the worst defense in the league (47 goals conceded), in contrast to Leipzig (18), which duly scored with the game’s first attack in the sixth minute when Yussuf Poulsen took advantage of some lax defending to score from close range.ADVERTISEMENT US judge bars Trump’s health insurance rule for immigrants ‘We are too hospitable,’ says Sotto amid SEA Games woes LATEST STORIES MOST READ But Steven Zuber equalized from the penalty spot 10 minutes later after the video referee intervened when Leipzig captain Willi Orban appeared to push Mario Gomez and deflect the ball out of play with his hand.The home side pushed for more — Leipzig ‘keeper Peter Gulacsi made a great save to deny Santiago Ascacibar in the second half — before Marcel Sabitzer restored the visitors’ lead from a free kick in the 68th.Midfielder Tyler Adams then won a challenge before setting Poulsen through to seal it in the 74th. It was Adams’ first assist in his fourth game since his winter transfer from the New York Red Bulls.SCHALKE FRUSTRATEDSchalke, which hosts Manchester City in the Champions League on Wednesday, was held at home by Freiburg to 0-0.Schalke midfielder Suat Serdar was shown a straight red card minutes before the break for a studs-up lunge at Freiburg captain Mike Frantz, who needed treatment.Both sides finished with 10 men after Freiburg’s Christian Guenter was shown his second yellow card in injury time for colliding with Mark Uth.Hoffenheim defeated Hannover 3-0, though the home side should have won by more. BERLIN — Claudio Pizarro scored in the sixth minute of injury time to salvage a 1-1 draw for Werder Bremen at Hertha Berlin and become the oldest ever goal-scorer in the Bundesliga on Saturday.Pizarro, aged 40 years and 136 days, broke the previous record held by Bremen midfielder Miroslav “Mirko” Votava (40 years, 121 days) from 1996, when he fired his free kick through a host of Hertha legs and past the helpless Rune Jarstein in goal.ADVERTISEMENT Sports Related Videospowered by AdSparcRead Next PH underwater hockey team aims to make waves in SEA Games PLAY LIST 02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss ‘We are too hospitable,’ says Sotto amid SEA Games woes Tim Tebow says he advised Kyler Murray to follow his heart Don’t miss out on the latest news and information. last_img read more